Pharmacological Activity of Flavonoids
Keywords:
Favonoids, Pharmacological Activity, Antioxidant, Anti-inflammatoryAbstract
Flavonoids are a diverse group of polyphenolic compounds widely distributed in fruits, vegetables, and medicinal plants, known for their significant pharmacological activities. These natural compounds exhibit strong antioxidant properties by scavenging free radicals and reducing oxidative stress, which plays a crucial role in preventing chronic diseases. Flavonoids also demonstrate anti-inflammatory activity by inhibiting key enzymes and cytokines involved in inflammatory pathways. Additionally, they possess antimicrobial effects against a broad spectrum of bacteria, viruses, and fungi, contributing to their therapeutic potential in infectious diseases. Flavonoids are a diverse group of polyphenolic compounds widely distributed in fruits, vegetables, and medicinal plants, known for their significant pharmacological activities. These natural compounds exhibit strong antioxidant properties by scavenging free radicals and reducing oxidative stress, which plays a crucial role in preventing chronic diseases. Flavonoids also demonstrate anti-inflammatory activity by inhibiting key enzymes and cytokines involved in inflammatory pathways. Additionally, they possess antimicrobial effects against a broad spectrum of bacteria, viruses, and fungi, contributing to their therapeutic potential in infectious diseases.
References
Rusznyák S, Szent-Györgyi A. Vitamin P: Flavonols as vitamins. Nature. 1936;138(3479):27. doi:10.1038/138027a0.
Pietta PG. Flavonoids as antioxidants. J Nat Prod. 2000;63(7):1035-42. doi:10.1021/np9904509.
Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr. 2001;74(4):418-25. doi:10.1093/ajcn/74.4.418.
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal. 2013;2013:162750. doi:10.1155/2013/162750.
Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. J Nutr Sci. 2016;5:e47. doi:10.1017/jns.2016.41.
Ullah A, Munir S, Badshah SL, Khan N, Ghani L, Poulson BG, et al. Important flavonoids and their role as a therapeutic agent. Molecules. 2020;25(22):5243. doi:10.3390/molecules25225243.
Safe S, Jayaraman A, Chapkin RS, Howard M, Mohankumar K, Shrestha R. Flavonoids: structure-function and mechanisms of action and opportunities for drug development. Toxicol Res. 2021;37(2):147-62. doi:10.1007/s43188-020-00080-z.
Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as potential anti-inflammatory molecules: a review. Molecules. 2022;27(9):2901. doi:10.3390/molecules27092901.
Shamsudin NF, Ahmed QU, Mahmood S, Shah SAA, Sarian MN, Khattak MMAK, et al. Flavonoids as antidiabetic and anti-inflammatory agents: a review on structure-activity relationship-based studies and meta-analysis. Int J Mol Sci. 2022;23(20):12605. doi:10.3390/ijms232012605.
Chen S, Wang X, Cheng Y, Gao H, Chen X. A review of classification, biosynthesis, biological activities and potential applications of flavonoids. Molecules. 2023;28(13):4982. doi:10.3390/molecules28134982.
Hassanpour SH, Doroudi A. Review of the antioxidant potential of flavonoids as a subgroup of polyphenols and partial substitute for synthetic antioxidants. Avicenna J Phytomed. 2023;13(4):354-76. doi:10.22038/AJP.2023.21774.
Gajender, Mazumder A, Sharma A, Azad MAK. A comprehensive review of the pharmacological importance of dietary flavonoids as hepatoprotective agents. Evid Based Complement Alternat Med. 2023;2023:4139117. doi:10.1155/2023/4139117.
Majee C, Mazumder R, Choudhary AN, Salahuddin, Manmohan, Kansal P, et al. An insight into the hepatoprotective activity and structure-activity relationships of flavonoids. Mini Rev Med Chem. 2023;23:131-49. doi:10.2174/1389557522666220602141142.
Hao B, Yang Z, Liu H, Liu Y, Wang S. Advances in flavonoid research: sources, biological activities, and developmental prospectives. Curr Issues Mol Biol. 2024;46(4):2884-2925. doi:10.3390/cimb46040181.
Bouyahya A, Balahbib A, Khalid A, Makeen HA, Alhazmi HA, Albratty M, et al. Clinical applications and mechanism insights of natural flavonoids against type 2 diabetes mellitus. Heliyon. 2024;10(9):e29718. doi:10.1016/j.heliyon.2024.e29718.
Wang M, Yu F, Zhang Y, Chang W, Zhou M. The effects and mechanisms of flavonoids on cancer prevention and therapy: focus on gut microbiota. Int J Biol Sci. 2022;18(4):1451-75. doi:10.7150/ijbs.68170.
Kopustinskiene DM, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as anticancer agents. Nutrients. 2020;12(2):457. doi:10.3390/nu12020457.
Górniak I, Bartoszewski R, Króliczewski J. Comprehensive review of antimicrobial activities of plant flavonoids. Phytochem Rev. 2019;18:241-72. doi:10.1007/s11101-018-9591-z.
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