Formulation and Evaluation of Transdermal Drug Delivery Systems of Labetalol Hydrochloride

Abstract

Transdermal drug delivery systems (TDDS) represent an advanced, non-invasive approach to systemic drug administration. This research focuses on the formulation and evaluation of TDDS containing Labetalol Hydrochloride, a drug used for managing hypertension and cardiovascular disorders. The study reviews the structural complexity of the skin and its role as a drug delivery barrier, examines key literature on TDDS development and highlights innovations such as microneedles and novel polymers. Materials and methods include solubility studies, partition coefficient evaluation, differential scanning calorimetry and penetration enhancer screening. Results show that DMSO was the most effective enhancer, increasing permeability by approximately 17%. Elevated drug concentration and enhancer levels correlated with higher permeation rates. These findings underscore the potential of optimized TDDS to improve therapeutic efficacy and patient compliance.